Search results for "system b"

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

2018

International audience; C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 1…

BioMet14 XIV PharmacoBioMetallics Pisa, 24-25 ottobre 2014

2014

Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study

2011

Abstract Background Studies of the apoptosis mechanisms involved in the pathogenesis of tuberculosis have suggested that Mycobacterium tuberculosis can actively interfere with the apoptosis of infected cells. In vivo studies have been performed in adult populations but have not focused on this process in children. In the present study, we analyzed spontaneous T lymphocyte (PBT) apoptosis in the peripheral blood of children with central nervous system tuberculosis (CNS TB), before and after chemotherapy, and compared the results with healthy controls. Methods A case-control study was conducted from January 2002 to June 2009. It included 18 children with CNS TB and 17 healthy controls. Sponta…

Hypervisor-based Protection of Code

2019

The code of a compiled program is susceptible to reverse-engineering attacks on the algorithms and the business logic that are contained within the code. The main existing countermeasure to reverse-engineering is obfuscation. Generally, obfuscation methods suffer from two main deficiencies: 1) the obfuscated code is less efficient than the original and 2) with sufficient effort, the original code may be reconstructed. We propose a method that is based on cryptography and virtualization. The most valuable functions are encrypted and remain inaccessible even during their execution, thus preventing their reconstruction. A specially crafted hypervisor is responsible for decryption, execution, a…

A Knowledge Based Decision Support System for Bioinformatics and System Biology

2011

In this paper, we present a new Decision Support System for Bioinformatics and System Biology issues. Our system is based on a Knowledge base, representing the expertise about the application domain, and a Reasoner. The Reasoner, consulting the Knowledge base and according to the user’s request, is able to suggest one or more strategies in order to resolve the selected problem. Moreover, the system can build, at different abstraction layers, a workflow for the current problem on the basis of the user’s choices, freeing the user from implementation details and assisting him in the correct configuration of the algorithms. Two possible application scenarios will be introduced: the analysis of …

Routing quantum information in spin chains

2013

Two different models for performing efficiently routing of a quantum state are presented. Both cases involve an XX spin chain working as data bus and additional spins that play the role of sender and receivers, one of which is selected to be the target of the quantum state transmission protocol via a coherent quantum coupling mechanism making use of local/global magnetic fields. Quantum routing is achieved, in the first of the models considered, by weakly coupling the sender and the receiver to the data bus. In the second model, strong magnetic fields acting on additional spins located between the sender/receiver and the data bus allow us to perform high fidelity routing.

Sustainable Infrastructure Projects: Systemic versus Traditional Delivery Models

2021

Sustainability involves multiple environmental, technical, social and economic factors, and such complex analysis requires systemic solutions. Delivery models are key to achieving system benefits and enhancing sustainable development in infrastructure investments. They define the phases of a project, incentive structures, risk sharing and the relationships among the actors in it. They are usually developed early in the project and determine the project dynamics and outcomes. We compared traditional delivery models with systemic ones. We identified and illustrated elements that differ between them through two cases. The contribution is an increased understanding of how systemic infrastructur…

Exploring Changes in Fishery Emissions and Organic Carbon Impacts Associated With a Recovering Stock

2022

International objectives for sustainable development and biodiversity conservation require restoring fish populations to healthy levels and reducing fishing impacts on marine ecosystems. At the same time, governments, retailers, and consumers are increasingly motivated to reduce the carbon footprint of food. These concerns are reflected in measures of the EU Common Fisheries Policy (CFP) and the CFP Reform Regulation, which highlighted a need to move from traditional single-stock management toward an ecosystem approach to fisheries management (EAF). Using publicly available landings and effort data combined with estimates of adult population biomass, we develop methods to explore the potent…

ON THE “SOLAR SYSTEM SMALL BODIES” ASTROPLATE PROJECT OF THE UKRAINIAN VIRTUAL OBSERVATORY

2019

The UkrVO Joint Digital Archive of astro- plates and the newest digitized data processing services al- lowed us to form a new approach for the creation of catalogs of astrometric and photometric characteristics of the Solar System bodies. Given this, the main goal of this approach was not only to complete the processing with the best possi- ble accuracy of high-quality and unprocessed earlier photo- graphic observations of the Solar System bodies but also to find new original data from these observations. As a result, more than 6,500 new astrometric positions and stellar magnitudes of asteroids, and 3,036 positions of outer planets (Pluto, Uranus, Neptune, Saturn, Jupiter) and their satelli…

INCREMENTI TERMICI IN VITRO UTILIZZANDO DUE DIVERSI SISTEMI DI OTTURAZIONE CANALARE A CALDO: SISTEMA E&Q VS SYSTEM B

2009

OBIETTIVO DELLA RICERCA: Una delle più comuni cause di insuccesso in Endodonzia è certamente rappresentata dall’incompleta otturazione del sistema dei canali radicolari, in tal senso, un materiale da otturazione canalare dovrebbe penetrare e diffondere in modo omogeneo in tutto lo spazio endodontico. La guttaperca è il più comune materiale da otturazione usato e viene comunemente utilizzata in associazione con il cemento canalare. Sono da preferire tecniche che prevedono quantità minime di cemento, come la condensazione verticale a caldo. L’originale tecnica di compattazione verticale a caldo è stata modificata da Buchanan che ha introdotto la tecnica dell’onda continua di condensazione med…